PROJECTS

Single-cell omics technologies and assays for parallel read-outs of chromatin accessibility, epigenetic states, transcription factor binding, gene expression, genome topology and assessing non-linear models of transcriptional control by cis-regulatory elements.

Motifs are unique to each transcription factor (TF). High-throughput assays such as SELEX, NCAP-SELEX & FIBER-SEQ reveal these TF-specific footprints, which can be associated to TF activity, modes of gene expression regulation and TF-DNA pairs that are key regulatory nodes in different cell-types.